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Case Reports in Endocrinology
Volume 2017 (2017), Article ID 4271978, 4 pages
https://doi.org/10.1155/2017/4271978
Case Report

Severe Short Stature in an Adolescent Male with Prader-Willi Syndrome and Congenital Adrenal Hyperplasia: A Therapeutic Conundrum

1The Warren Alpert Medical School, Brown University, Providence, RI, USA
2College of Human Ecology, Cornell University, Ithaca, NY, USA
3Alexian Brothers Women and Children’s Hospital and Amita Health Medical Group, Hoffman Estates, IL, USA
4Division of Pediatric Endocrinology, Rhode Island Hospital and Hasbro Children’s Hospital, The Warren Alpert Medical School, Brown University, Providence, RI, USA

Correspondence should be addressed to Jose Bernardo Quintos; ude.nworb@sotniuqbj

Received 4 April 2017; Accepted 10 May 2017; Published 30 May 2017

Academic Editor: Wayne V. Moore

Copyright © 2017 Meredith Wasserman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency results in excess androgen production which can lead to early epiphyseal fusion and short stature. Prader-Willi syndrome (PWS) is a genetic disorder resulting from a defect on chromosome 15 due to paternal deletion, maternal uniparental disomy, or imprinting defect. Ninety percent of patients with PWS have short stature. In this article we report a patient with simple-virilizing CAH and PWS who was overtreated with glucocorticoids for CAH and not supplemented with growth hormone for PWS, resulting in a significantly short adult height.