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Case Reports in Endocrinology
Volume 2017, Article ID 4581626, 5 pages
Case Report

Anaplastic Spindle Cell Squamous Carcinoma Arising from Tall Cell Variant Papillary Carcinoma of the Thyroid Gland: A Case Report and Review of the Literature

1Department of Surgery, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK
2Department of Surgery and Cancer, The Imperial Centre for Translational and Experimental Medicine, Imperial College London, Hammersmith Campus, London, UK
3Department of General Medicine, Wexham Park Hospital, NHS Frimley Health Foundation Trust, London, UK
4Department of Life Sciences, Imperial College London, London, UK
5Department of Histopathology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK

Correspondence should be addressed to Darren K. Patten; moc.liamg@nettap.nerrad

Received 23 January 2017; Accepted 22 March 2017; Published 6 April 2017

Academic Editor: Najmul Islam

Copyright © 2017 Darren K. Patten et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tall cell variant (TCV) of papillary thyroid carcinoma (PTC), an aggressive form of thyroid cancer, is characterised by 50% of cells with height that is three times greater than the width. Very rarely, some of these cancers can progress to spindle cell squamous carcinoma (SCSC) resulting in cancers with elements of both SCSC and TCV PTC. Here we report a case of SCSC arising from TCV PTC. In addition to this case, we have performed a literature review and compiled all published reports of SCSC arising from TCV PTC, including the nature of treatment and the prognosis for each of the 20 patients recorded. This is intended for use as a guide for clinicians in what the most appropriate treatment options may be for a newly diagnosed patient. Due to the rarity coupled with diagnosis occurring at a very advanced stage of disease progression, performing clinical trials is difficult and therefore drawing conclusions on optimal treatment methods remains a challenge.