Anaplastic Spindle Cell Squamous Carcinoma Arising from Tall Cell Variant Papillary Carcinoma of the Thyroid Gland: A Case Report and Review of the Literature

Figure 4

Histology of the tumour. (a) Features of papillary carcinoma including papillary architecture (with tall, well-formed papillae) and tumour cells that were columnar in shape, with nuclei showing overlapping, clearing, and pseudoinclusions. (b) Moderately to poorly differentiated squamous cell carcinoma. (c) Moderately to poorly differentiated squamous cell carcinoma with spindle cell elements. (d) Positive for (nuclear) thyroid transcription factor-1 (TTF-1) and Galectin-3 (cytoplasmic) in both components.

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