Adrenal Oncocytic Neoplasm with Paradoxical Loss of Important Mitochondrial Steroidogenic Protein: The 18 kDA Translocator Protein

Figure 1

Composite figure illustrating imaging, surgical, histologic, and ultrastructural findings. (a) Sagittal CT scan shows a large ovoid mass (arrow) abutting the liver and the superior pole of the right kidney. (b) Surgical resection specimen highlights the bright yellow tumor parenchyma as well as a portion of the patient’s residual adrenal gland (arrows). (c) Microscopic examination of adrenal oncocytic neoplasm composed of large cells with abundant pink granular cytoplasm and irregular nuclei with prominent nucleoli (H&E, 20x). The insert highlights the presence of areas displaying marked nuclear pleomorphism and atypia (H&E, 40x). (d) Transmission electron microscopy illustrating a tumor cell at the center of the image with a large centrally located oval nucleus and abundant mitochondria occupying most of the cytoplasm. H&E: hematoxylin and eosin.

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