Short Stature Homeobox-Containing Haploinsufficiency in Seven Siblings with Short Stature

Table 1

Results of growth hormone (GH) treatment in seven siblings with short stature due to SHOX haploinsufficiency.

Case	Sex	Age at onset of GH (years)	Bone age at onset of GH (years)	Duration of GH treatment (years)	Height SDS at initiation of GH	Height SDS in June 2014	Change in Height SDS
1	M	3.8	3.5	9.3	−3.1	−1.06	+2.04
2	M	2.9	1.5	8.5	−2.71	−0.77	+1.94
3	F	9.3	8.8	4.5	−2.48	−1.42	+1.06
4	M	10.6	10	4.3	−2.42	−1.83	+0.59
5	F	1.8	2	4.3	−2.57	−2.23	+0.34
6	F	1.5	1.3	3.5	−3.00	−2.52	+0.48
7	M	1.8	2	2.1	−2.26	−1.41	+0.85