Giant Prolactinoma of Young Onset: A Clue to Diagnosis of MEN-1 Syndrome

Table 1

Suggested biochemical and radiological screening in individuals with MEN1 mutations [7].

Tumour	Age to begin(y)	Biochemical test annually	Imaging test (Time interval)
Parathyroid	8	Calcium, PTH	None
Pancreas	20	Gastrin	None
Gastrinoma
Insulinoma	5	Fasting glucose, Insulin	None
Other pancreatic; NET	<10	Chromogranin-A, PP, glucagon, VIP	MRI, CT or endoscopic US
Pituitary	5	Prolactin, IGF-1	MRI (every 3 y)
Adrenal	19	None unless >1cm lesion or symptoms	MRI or CT
Thymic and; bronchial carcinoid	15	None	CT or MRI(1-2y)