Thyroseq V3 Molecular Profiling for Tailoring the Surgical Management of Hürthle Cell Neoplasms

Figure 1

(a) FNA diagnosis: Hürthle cell neoplasm or suspicious for a Hürthle cell neoplasm, Bethesda Category IV. The aspirate shows predominantly single cells, many with degenerated friable cytoplasm, imparting a pseudo-necrotic background (A). The cells have abundant granular eosinophilic cytoplasm with eccentric and slightly enlarged nuclei, giving a plasmacytoid appearance (ThinPrep, Papanicolaou x 40). The neoplastic cells stain with pankeratin AE1/AE3 (B), TTF-1 (C), and thyroglobulin (D), confirming their thyroid follicular origin and excluding medullary carcinoma or histiocytes

(b) Invasive, follicular carcinoma, oncocytic (Hürthle cell) variant. The tumor shows a trabecular/solid architecture (A), composed of large, polygonal cells with abundant granular eosinophilic cytoplasm. The cells have round to slightly irregular nuclei with prominent centrally placed nucleoli (B). Foci of capsular (A) and vascular invasion are identified (C, D)