Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis

Table 2

Characteristics and specific organ involvement of cases of diabetes mellitus associated with LCH.

Age at diagnosis of histiocytosis (years)	Sex	Diagnosis of histiocytosis	Diabetes insipidus	Delay between diagnosis of histiocytosis and diabetes	Pathophysiology of diabetes	Daily insulin needs	Reference
31	M	Bone biopsy	+	2 years	Central obesity, insulin resistance	NA	[11]
60	F	Autopsy (histiocytes cells in vertebral marrow, pituitary, lung	+	3 years	Central obesity, insulin resistance	3300 UI/day	[12]
26	M	Autopsy (histiocytes cells in pancreas)	+	2 years	Destruction of pancreatic islets by pancreas infiltration of histiocytosis	80UI/day	[7]
28	F	Lymph node biopsy	+	Few months	Central obesity, insulin resistance	NA	[13]
NA	M	Autopsy (histiocytes cells in skin, liver, bones)	-	6 months	NA	NA	[14]
54		Central nervous system, bones	+	NA	Glucocorticoids, overweight	NA	[15]
60	F	Central nervous system, bones	+	NA	Overweight	NA	[15]
54	M	Gengives	+	NA	Glucocorticoids, overweight	NA	[15]
45	F	Bones, lung, lymph nodes	-	NA	Obesity	NA	[15]