Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes

Figure 1

Representative immunofluorescence images of a pancreatic section stained for leucocyte common antigen CD45 (red), C-peptide (green), glucagon (white), nuclei DAPI (blue), illustrating variable immune infiltration of pancreatic parenchyma and islets. (b) and (d) are high magnification images of islets in (a) and (c) respectively. (b) shows the focal aggregation of CD45+ cells at one pole of the islet typical in early T1D and referred to as peri-insulitis.