Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes

Figure 2

(a) Representative image of pancreatic section stained with H&E: NP-normal parenchyma, ^∗—fat deposition, # — fibrosis, i —a site of inflammation next to the area of acinar-to-ductal metaplasia (box). (b) Cross-sectional view of CT scan slice of the pancreas showing normal density of the head of the pancreas while the neck, body and tail show low density consistent with fatty replacement acinar tissue. (c) High magnification of the boxed area (in (a)) illustrating acinar to ductal metaplasia (arrow) versus normal acinar tissue (arrow head). (d) Image of the same area in the adjacent section immunostained with anti-cytokeratin (green), Ki67 (red) and C-peptide (white).