Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes

Figure 3

Representative immunofluorescence images of the pancreatic sections stained for macrophage marker CD68 (red), insulin (green), glucagon (white) in panels (a–c), or for T cell markers CD3 and CD8 (red and white respectively) and insulin (green) in panels (d and e); blue -nuclei (DAPI). Macrophages were found in peri-islet area (a–c, arrows) or pancreatic parenchyma (b, arrow head). CD8+CD3+ T cells were frequent throughout the parenchyma (d and e, arrow heads), in the areas of acinar-to-ductal metaplasia (d, e, arrow heads), and in the peri-islet area (d–f, arrows).