Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes

Figure 4

Representative immunofluorescence images of a pancreatic section stained for leucocyte common antigen CD45 (red), insulin (green), glucagon (white), nuclei DAPI (blue). Leucocytes are presented scattered throughout the exocrine pancreas as well as in occasional focal aggregates (a, arrow). Leucocytes are also present in areas of acinar-to-ductal metaplasia illustrated in (b). While most islets in this case had beta cells present, as expected in evolving type 1 diabetes, occasional islets were present with no detectable beta cells (c, arrow) or a few beta cells with minimally insulin immunoreactivity (d, arrow).