Case Report
Triglyceride Levels Greater Than 10,000 mg/dL in a 49-Year-Old Female without Evidence of Pancreatitis
Table 2
Fredrickson classification of primary hypertriglyceridemia [
6,
8].
| TYPE | ELEVATED LIPOPROTEIN | LIPID PROFILE | CLINICAL MANIFESTATIONS | RELATIVE FREQUENCY |
| I – Familial chylomicronemia | Chylomicron | TC + TG +++ | Presents in infancy, eruptive xanthomas, recurrent pancreatitis, failure to thrive | <1% |
| II b – Familial Combined Hyperlipidemia | LDL, VLDL, Apo-B | TC ++ TG ++ | Xanthomas less common. Risk of premature CVD | 40% |
| III – Familial dysbetalipoproteinemia | IDL | TC ++ TG ++ | Palmar xanthomas, risk of premature CVD | <1% |
| IV – Familial Hypertriglyceridemia | VLDL | TC + TG ++ | Associated w/ DM, insulin resistance, obesity, HTN | 45% |
| V – Primary Mixed Hyperlipidemia | Chylomicron, VLDL | TC +++ TG +++ | Similar to type I but develops in adulthood | 5% |
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TC = total cholesterol; TG = triglycerides; DM = Diabetes Mellitus; HTN = Hypertension; CVD = cardiovascular disease; LDL = low-density lipoprotein; VLDL = very low-density lipoprotein; IDL = intermediate density lipoprotein; Apo-B = apolipoprotein B.
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