An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature

Table 2

Clinical and biochemical features of 15 patients with coexistence of parathyroid and thyroid carcinoma.

Reference	Age	Gender	Calcium (mg/dL)	PTH (pg/mL)	Parathyroid gland size (cm)	Carcinoma location	Thyroid carcinoma	Associated parathyroid disease	Surgical treatment	Outcome
Kurita et al. [38]	68	F	12.2	6300	4.2 × 3.2 × 2.4	Left lower	Papillary	None	En bloc resection	Postoperative normocalcemia
Christmas et al. [26]	62	F	Hypercalcemia	Unknown	Unknown	Unknown	Follicular	None	Unknown	Died from metastatic parathyroid carcinoma
Savli et al. [22]	47	F	Normal	Normal	Normal	Unknown	Papillary	Hyperplasia	Total thyroidectomy parathyroidectomy (excision of 2 hyperplastic glands)	Normocalcemia (1 year)
Bednarek-Tupikowska et al. [27]	42	F	15.4	1655	5 cm in diameter	Left lower	Follicular	None	En bloc resection	Persistent hypercalcemia
Schoretsanitis, 2002 [24]	55	F	14.2	>1000	3 × 3	Left lower	Papillary	None	En bloc resection	Normocalcemia (6 years)
Kern et al. [28]	54	F	Unknown	465	2.5 × 1.8 × 1.6	Right lower	Papillary and follicular	None	Right parathyroidectomy; total thyroidectomy with local lymph node resection; corticectomy in the right superior frontal gyrus	Died from intracranial metastatic parathyroid carcinoma
Lin et al. [25]	38	M	16.5	351	4 × 3 × 3	Left lower	Papillary	Two enlarged parathyroid glands on contralateral side	Total thyroidectomy and left parathyroidectomy	Normocalcemia (6 years)
Goldfarb et al. [16]	58	M	14.4	2023	3.4 × 3.3 × 2.2	Left lower	Papillary	Contralateral parathyroid adenoma	En bloc resection	Persistent hypercalcemia after resection of parathyroid carcinoma; normocalcemia after excision of contralateral parathyroid adenoma (1 year)
Marcy et al. [17]	42	F	14.1	383	1.3	Right lower	Papillary	None	Total thyroidectomy, right parathyroidectomy, and central and lateral neck dissection	Normocalcemia (14 months)
Chaychi et al. [18]	79	F	10.4	89	1.1 × 1.2 × 4.8	Left superior	Papillary	None	Total thyroidectomy and left parathyroidectomy	Normocalcemia (6 months)
Amoodi et al. [19]	48	F	Unknown	186	>5	Left lower	Papillary	None	En bloc resection	Persistent hypercalcemia after resection of parathyroid carcinoma; hypoparathyroidism after completion of parathyroidectomy
Zakerkish et al. [21]	21	M	13	1311	Unknown	Unknown	Hürthle	None	Total thyroidectomy and parathyroidectomy	Persistent hypercalcemia and died due to its complications
Song et al. [30]	45	F	17	1455	4.28 × 3.09 × 2.54	Left lower	Papillary	None	Left parathyroidectomy and left thyroid lobectomy plus left neck dissection	Persistent hypercalcemia after left parathyroidectomy; normocalcemia after left thyroid lobectomy plus left neck dissection (6 months)
Baek et al. [23]	68	F	12.8	1247	4.2 × 3.3 × 3.1	Left lower	Papillary	None	Left inferior parathyroidectomy and left thyroid lobectomy	Postoperative normocalcemia
Kuzu et al. [29]	52	F	11.4	208	Unknown	Unknown	Papillary	None	Right parathyroidectomy and right thyroid lobectomy	Postoperative normocalcemia
Our case	50	F	13.9	1160	2.4 × 1.8 × 1.4	Left superior	Papillary	None	Left inferior parathyroidectomy and left thyroid lobectomy	Postoperative normocalcemia