The Use of ^99mTc-Methoxy-isobutyl-isonitrile (sestaMIBI) Uptake on Scintigraphy (^99m-STS) in Amiodarone-Induced Thyrotoxicosis: Case Series and Review of the Literature

Table 3

Summary of the different literature using ^99m-STS in AIT.

Study	Type of the study	Number of patients	Country	Results
Piga et al. [17]	Prospective	20 patients	Italy	^99m-STS can be proposed as an easy and highly effective diagnostic tool for the differential diagnosis of AIT, with positive persistent scans in AIT-1 and negligible uptake in AIT-2. It appears also to give some insights into indeterminate forms of AI.; ^99m-STS is superior to all other diagnostic tools including CFDS and RAIU.
Oki et al. [24]	Prospective	23 patients on amiodarone for more than 4 months (4 out of 23 patients had AIT)	Brazil	^99m-STS may be an alternative tracer for thyroid scintigraphy and uptake measurement of patients on chronic use of amiodarone.; ^99m-STS seems to be better than Tc-99m pertechnetate for the scintigraphic evaluation of the thyroid in euthyroid and hyperthyroid patients.
Souto et al. [22]	Case report	1 patient	Portugal	^99m-STS used to diagnosis undetermined AIT.
Pattison et al. [19]	Retrospective	15 patients	Australia	Use of quantitative TBR improves the interobserver reliability of reporting ^99m-STS for investigation of different types of AIT.
Patel et al. [21]	Case report	1 patient	Houston	^99m-STS used to diagnosis AIT-1 in addition to the RAIU.
Victor et al. [23]	Case report	1 patient	Portugal	^99m-STS used to diagnosis undetermined AIT.
Wang and Zhang [18]	Prospective	15 patients	China	^99m-STS imaging alone can accurately distinguish types I and II and mixed-type AIT.
Censi et al. [8]	Retrospective	30 patients	Italy	^99m-STS combined with the TBR proved a very useful approach to the classification of AIT, enabling patients to be offered appropriate treatment as soon as they are diagnosed. It has 100% specificity and 91.7% sensitivity in differentiating different types of AIT.