Three Cases of Anaplastic Thyroid Carcinoma Transformation and Leukocytosis during Lenvatinib Treatment

Figure 1

Clinical course of Case 1. The upper image is a chest computed tomography (CT) image. Although lung metastasis did not change after three courses of radioactive iodine (RAI) treatment, the patient’s condition became progressive disease after anaplastic transformation and bilateral pleural effusion accumulated. The lower image is a CT image of the pelvis, and the left iliac metastasis increased rapidly after anaplastic transformation. The graph below the image shows the transition of thyroglobulin and antibodies, the timing of lenvatinib treatment and the dose. Whole body scintigraphy images after three RAI treatments are also shown in the background. RAI uptake is decaying. The red dotted circle indicates the lesion. The red arrow indicates the time of anaplastic transformation.