Prolactin-Secreting Leiomyoma Causing Hyperprolactinaemia Unresponsive to Dopamine Agonist Therapy and Resolution following Myomectomy

Table 2

Published case reports of ectopic secretion of prolactin from uterine leiomyomas.

Article reference	Age of patient	First clinical manifestations	Peak prolactin reported (mIU/L)	Dopamine agonist therapy	Dose cabergoline	Prolactin response	Histopathology	Size of leiomyoma	Time to diagnosis	Immunostaining for prolactin
[3]	47	Galactorrhoea	4765	Cabergoline	2 mg/week	Refractory	Leiomyoma	13.9 × 10.4 × 11.8 cm	10 months	Positive
[5]	44	Amenorrhoea	4638	Bromocriptine	30 mg/day	Refractory	Leiomyoma	8 × 7 cm	10 years	Not reported
[6]	36	Irregular menstrual cycle, galactorrhea, and headaches	2127	Bromocriptine	15 mg/day	Refractory	Leiomyoma	5.5 cm	6 months	Not reported
[7]	25	Irregular menstrual cycle and galactorrhoea	3191	Cabergoline bromocriptine	Dose not specified	Refractory	Leiomyoma	6 × 7.2 × 8 cm	3 years	Negative
[8]	45	Not reported	Not reported	Bromocriptine	Not reported	Refractory	Leiomyoma	9 cm	6 months	Negative
[9]	41	Amenorrhea and galactorrhea	5900	Dopamine agonist—not specified	Not reported	Refractory	Leiomyoma	Not reported	6 years	Negative
This case	37	Irregular menstrual cycle and galactorrhea	1846	Cabergoline	1 mg/week	Refractory	Leiomyoma	15.2 cm × 9.1 cm × 12.1 cm	14 months	Negative