Case Report
Prolactin-Secreting Leiomyoma Causing Hyperprolactinaemia Unresponsive to Dopamine Agonist Therapy and Resolution following Myomectomy
Table 2
Published case reports of ectopic secretion of prolactin from uterine leiomyomas.
| Article reference | Age of patient | First clinical manifestations | Peak prolactin reported (mIU/L) | Dopamine agonist therapy | Dose cabergoline | Prolactin response | Histopathology | Size of leiomyoma | Time to diagnosis | Immunostaining for prolactin |
| [3] | 47 | Galactorrhoea | 4765 | Cabergoline | 2 mg/week | Refractory | Leiomyoma | 13.9 × 10.4 × 11.8 cm | 10 months | Positive | [5] | 44 | Amenorrhoea | 4638 | Bromocriptine | 30 mg/day | Refractory | Leiomyoma | 8 × 7 cm | 10 years | Not reported | [6] | 36 | Irregular menstrual cycle, galactorrhea, and headaches | 2127 | Bromocriptine | 15 mg/day | Refractory | Leiomyoma | 5.5 cm | 6 months | Not reported | [7] | 25 | Irregular menstrual cycle and galactorrhoea | 3191 | Cabergoline bromocriptine | Dose not specified | Refractory | Leiomyoma | 6 × 7.2 × 8 cm | 3 years | Negative | [8] | 45 | Not reported | Not reported | Bromocriptine | Not reported | Refractory | Leiomyoma | 9 cm | 6 months | Negative | [9] | 41 | Amenorrhea and galactorrhea | 5900 | Dopamine agonist—not specified | Not reported | Refractory | Leiomyoma | Not reported | 6 years | Negative | This case | 37 | Irregular menstrual cycle and galactorrhea | 1846 | Cabergoline | 1 mg/week | Refractory | Leiomyoma | 15.2 cm × 9.1 cm × 12.1 cm | 14 months | Negative |
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