Case Report
Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma
Table 3
The differential diagnosis markers between TSH-secreting adenomas (TSHomas) and resistance to thyroid hormones (RTH).
| | TSHoma | RTH |
| Family history of thyroid disease | Absent | 85% | Unsuppressed TSH or increased | Present | Present | Elevated thyroid hormone levels | Present | Present | Nycthemeral profile of TSH | Absent | Present | High levels of SHBG (TeBG) | Present | Absent | Increased α subunit | 65% | 3% | α-GSU/TSH molar ratio | >1% | <1% | Increase in TSH after a TRH | Negative | Positive | T3 suppression test | No TSH suppression | Suppression of TSH | Somatostatin test | FT4 ↓ >30% | FT4 is not affected | Multihormonal production | Possible | Absent | MRI pituitary | 98% | 10–20% | DNA mutation analysis | − | + |
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