Case Report
Successful Treatment of Tumor-Induced Osteomalacia by Multidisciplinary Therapy with Radiation to Intracranial Fibromyxoid Tumor
Table 2
Details of all published cases of radiotherapy use for TIO.
| | Reference | Case | Age | Sex | Histopathology | Lesion site | Previous surgery | Radiotherapy indication | Radiotherapy treatment modality | EBRT, total dose (Gy) | EBRT, fraction dose (Gy) | EBRT technique | Follow-up time (months) | Local tumor control | Status osteomalacia |
| | Uramoto, 2009 | 1 | 48 | M | Malignant PMTMCT | Tongue | Yes, 1 time | Unresectable recurrence of the lesion | EBRT | 66 | Not specified | Not specified | 24 | Unknown | Cured | | Tarasova, 2013 | 2 | 67 | F | Unknown | Intracranial | No | Surgery refusal | EBRT | 60 | Not specified | SRT | 12 | Unknown | Cured | | Hautmann, 2014 | 3 | 45 | M | PMTMCT | Distal tibia | Yes, 1 time | Postoperative, partial resection | EBRT | 45 | 1.8 | Not specified | 34 | Complete remission | Cured | | Basu, 2016 | 4 | 53 | F | Benign giant-cell tumor | Base of the skull | Yes, multiple | Unresectable recurrence of the lesion | PPRT (peptide receptor radiotherapy) | - | - | - | 3 | Partial response | Cured | | Shah, 2019 | 5 | 46 | M | Hemangiopericytoma | Left petrous tumor | Yes, 1 time | Postoperative, partial resection | EBRT | Not specified | Not specified | Not specified | 96 | Complete remission | Cured | | 6 | 53 | F | PMTMCT | Base of the skull | Yes, multiple | Postoperative, partial resection | PPRT (peptide receptor radiotherapy) | - | - | - | 13 | Stable disease | Cured | | 7 | 60 | M | PMTMCT | Left ethmoid sinus | Yes, multiple | Postoperative, partial resection | EBRT | 54 | 1.8 | IMRT | 36 | Unknown | Cured | | Present case | 8 | 52 | M | Ossifying fibromyxoid tumor | Frontal sinus | Yes, multiple | Postoperative, complete resection | EBRT | 60 | 2 | VMAT | 55 | Complete remission | Cured |
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PMTMCT, phosphaturic mesenchymal tumor mixed connective tissue type; EBRT, external beam radiotherapy; PPRT, peptide receptor radiotherapy; SRT, stereotactic radiotherapy; IMRT, intensity-modulated radiotherapy, VMAT, volumetric modulated arc therapy.
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