Case Reports in Endocrinology

Case Report

Two Case Reports of Subacute Thyroiditis after Receiving Vaccine for COVID-19

Table 1

A review of previously published cases of SAT associated with vaccination against SARS-CoV-2. Only SAT cases from each manuscript are listed in this table.
ReferenceGenderAgeVaccineDoseTime from vaccination until onset of symptomsSymptomsHistory of thyroid diseasefT3fT4TSHESR (mm) (RR < 15)TgAbTRAbTPO-ab
Our case 1F36BNT162b2 (Comirnaty®)2nd1 dayNeck pain, restlessness, fatigueNone↔↔↔44NegNegNeg
Our case 2M65ChAdOx1 (Vaxzevria®)1st3 daysMalaiseNone↔↔↓21PosNegNeg
Iremli et al. [11]              
Case 1F35PiCoVacc (CoronaVac®)2nd4 daysLeft-side anterior neck pain, fever, fatigue, palpitationsNone↑↔↔53NegNegNeg
Case 2F34PiCoVacc (CoronaVac®)1st4 daysAnterior neck pain, fever, fatigue, palpitationsNone↑↓↓19NegNegNeg
Case 3F37PiCoVacc (CoronaVac®)2nd7 daysMild anterior neck painNone↑↔↔25NegNegNeg
ReferenceGenderAgeVaccineDoseDays until symptomsSymptomsHistory of thyroid diseasefT3fT4TSHESR (mm) (RR < 15)TgAbTRAbTPO-Ab
Bornemann et al. [12]              
Case 1F26ChAdOx1 (Vaxzevria®)1st14 daysFever, cervical pain radiated in both earsNone↑↔↔NDNegNegNeg
Case 2F49mRNA-1273 (Spikevax®)1st14 daysSore throat with radiation to the ear, headacheNone↔↔↔NDNegNegNeg
Patel et al. [13]              
 M48ND2nd7 daysRight neck swelling, throat discomfort, palpitations, fever, weight lossNDND3.6 ng/dl (no RR)0.01 mIU/L (no RR)NDNDNDND
ReferenceGenderAgeVaccineDoseDays until symptomsSymptomsHistory of thyroid diseasefT3fT4TSHESR (mm) (RR < 15)TgAbTRAbTPO-ab
Saygili et al. [14]              
 F38PiCoVacc (CoronaVac®)2nd14 daysNeck swelling, pain, fatigue, loss of appetite, sweatingNone↑↔↓78NegNDNeg
 F34BBV152 (COVAXIN®)1st5–7 daysFever, palpitation, anterior neck painNone↑↑↓60NDNDND
Chatzi et al. [15]              
 F35BNT162b2 (Comirnaty®)1st12 daysNeck pain, fatigue, palpationsNDND↑↓75NegNegNeg
 F32BNT162b2 (Comirnaty®)2nd4 daysNeck pain, fatigueNDND↔↓40NegNegNeg
ReferenceGenderAgeVaccineDoseDays until symptomsSymptomsHistory of thyroid diseasefT3fT4TSHESR (mm) (RR < 15)TgAbTRAbTPO-ab
Kyriacou et al. 10/21 [16]              
 F40BNT162b2 (Comirnaty ®)2nd12 hoursMalaise, anterior neck pain,NoneND↑↓67PosNegNeg
Siolos et al. [17]              
 F51BNT162b2 (Corminaty®)1st4 daysNausea, mild anterior neck pain, feverNone↔↑↓103NegNegNeg
ReferenceGenderAgeVaccineDoseDays until symptomsSymptomsHistory of thyroid diseasefT3fT4TSHESR (mm) (RR < 15)TgAbTRAbTPO-ab
Jeeyavudeen et al. [18]              
 FNDBNT162b2 (Comirnaty®)2nd14 daysPainful swelling, poor sleep, night sweats, hyperdefecation, weight lossNone↑↑↓NDNegNDNeg
Plaza-Enriquez et al. [19]              
 F42mRNA-1273 (Spikevax®)2nd5–6 daysEarache radiating down to the neck and jaw,None↑↔↓81NDNDNeg
ReferenceGenderAgeVaccineDoseDays until symptomsSymptomsHistory of thyroid diseasefT3fT4TSHESR (mm) (RR < 15)TgAbTRAbTPO-ab
Khan et al. [20]              
 F42BNT162b2 (Comirnaty®)2nd4 daysFever, palpitations, painful left-sided neck swellingNDND↑↓60NDNegNeg
Sözen et al. [21]              
 M41BNT162b2 (Comirnaty®)2nd8 daysAnterior neck pain, fatigue, palpitationNone↑↑↓32NegNegNeg
 F40BNT162b2 (Comirnaty®)1st6 daysNeck pain, palpitation, sweatingNone↔↔↓34PosNegNeg
 M40BNT162b2 (Comirnaty®)1st4 daysNeck pain, nervousness, fatigueNone↔↔↔15NegNDNeg
ReferenceGenderAgeVaccineDoseDays until symptomsSymptomsHistory of thyroid diseasefT3fT4TSHESR (mm) (RR < 15)TgAbTRAbTPO-Ab
 F26BNT162b2 (Comirnaty®)2nd6 daysNeck painNone↑↑↓34PosNegPos
 F44BNT162b2 (Comirnaty®)2nd9 daysNeck pain, headache, palpitation, sweating, tremorHashimoto thyroiditis↔↔↓44NegNegPos
Schimmel et al. [22]              
 F57BNT162b2 (Comirnaty®)2nd1 dayAnterior neck pain, swellingNone↔↔↓NDNegNegNeg
Franquemont et al. [23]              
 F42BNT162b2 (Comirnaty®)1st5 daysSore throat, palpitationsNone11.8 (no RR)4.58 (no RR)<0.01 (no RR)62NegNegNeg
ReferenceGenderAgeVaccineDoseDays until symptomsSymptomsHistory of thyroid diseasefT3fT4TSHESR (mm) (RR < 15)TgAbTRAbTPO-ab
Oyibo et al. [24]              
 F55ChAdOx1 (Vaxzevria®)1st21 daysHeadache, sore throat, generalized aches, palpitationsNoneND↑↓51NDNDNeg
Sahin Tekin et al. [25]              
 M67PiCoVacc (CoronaVac®)2nd19 daysFever, mild neck pain,None↑↑↓67NegNegNeg
ReferenceGenderAgeVaccineDoseDays until symptomsSymptomsHistory of thyroid diseasefT3fT4TSHESR (mm) (RR < 15)TgAbTRAbTPO-ab
Pla Peris et al. [26]              
 M67mRNA-1273 (Spikevax®)1st10–14 daysNeck pain radiating to the ears, asthenia, mild fever, tachykardiaNoneND↑↓60NegNegPos
 M47BNT162b2 (Comirnaty®)1st10–14 daysNeck pain radiating to the ears, asthenia, mild fever, tachykardiaNoneND↔↓70NegNegNeg
Note: the pathological values are printed in bold. fT3: free triiodothyronine; fT4: free thyroxine; TSH: thyroid-stimulating hormone; ESR: erythrocyte sedimentation rate; TgAb: antithyroglobulin antibody; TRAb, TSH receptor antibodies; TPO-Ab: thyroid peroxidase antibody; pos: positive; neg: negative; ND: no data; RR : reference range; ↔: normal; ↑: increased; ↓: decreased.