Case Series

Switching from Natural Desiccated Thyroid to a Liquid Formulation of Levothyroxine for Hypothyroidism

Table 2

Baseline patient demographics and disease characteristics.

PatientSexAge (years)BMI (kg/m2)Primary thyroid diagnosisComorbiditiesPrior thyroid treatmentMedications/supplementsReason for switchAllergiesSymptoms

AF5917.9(i) Autoimmune thyroiditis12, including celiac diseaseWP Thyroid 2 grain (130 mg) and then switched to NP Thyroid 2 grain (120 mg) due to WP Thyroid recall13, including ferrochel (iron chelate)Symptoms(i) Sulfur
(ii) Diladon
(iii) Gluten
(i) Abdominal pain
(ii) Nausea
(iii) Menopausal symptoms of hot flashes and night sweats

BF4732.5(i) Hypothyroidism
(ii) Multinodular goiter
11WP Thyroid and then switched to NP Thyroid 2.5 grain (150 mg)5Symptoms(i) Sulfa drugs
(ii) Penicillin
(iii) MSG
(iv) Wheat
(v) Dairy
(i) History of thyroid disorder
(ii) Noncompliant with diabetes medications
(iii) Hot flashes
(iv) Abdominal flatulence

CF6428.9(i) Autoimmune thyroiditis
(ii) Hypothyroidism
(iii) Nontoxic goiter
6NP Thyroid 90 mg (1.5 grains)6SymptomsNone known(i) History of hypothyroidism

DF4117.9(i) Autoimmune thyroiditis (Hashimoto’s disease)6Armour Thyroid 90 mg12, including a multivitamin with ironSymptomsNone known(i) Fatigue
(ii) Moodiness
(iii) Irritability
(iv) Depression

EF4919.9(i) Hypothyroidism7, including celiac diseaseArmour Thyroid, then NP Thyroid, and then compounded thyroid medication15Symptoms(i) Ciprofloxacin
(ii) Weeds
(iii) Trees
(iv) Grasses
(i) Fatigue
(ii) Irregular periods
(iii) Allergies

FF6023(i) Autoimmune thyroiditis (Hashimoto’s disease)5, including celiac diseaseNDT and then compounded levothyroxine/liothyronine 90/25 μg18Symptoms(i) Sulfa
(ii) Gluten
(iii) Dust
(iv) Lactose
(i) History of Hashimoto’s disease

GF5626.5(i) Hypothyroidism5Nature Thyroid 1.5 grain8Symptoms(i) Naproxen
(ii) Eggs
(iii) Almonds
(iv) Bananas
(i) Hypothyroidism
(ii) Constipation
(iii) Fatigue
(iv) Weight gain

HF65N/A(i) Hypothyroidism5NP Thyroid 60 mg10, including multivitamin with ironSymptoms(i) Sulfa drugs(i) Stress
(ii) Hives
(iii) Hair loss

IF53N/A(i) Autoimmune thyroiditis (Hashimoto’s disease)6WP Thyroid and then Synthroid and T3 sustained release13, including ironSymptoms(i) Cefalexin
(ii) Epinephrine
(iii) Adhesives
(iv) Iodine contrast
(i) Menopause
(ii) Autoimmunity
(iii) GI concerns

JF6519.9(i) Autoimmune thyroiditis7Armour Thyroid and then NP Thyroid 90 mg = 1.5 grains12Symptoms(i) Penicillin
(ii) Dairy
(iii) Gluten
(iv) Soy
(v) Mold
(i) History of Hashimoto’s disease
(ii) Hair loss
(iii) Difficulty sleeping

KF3024(i) Autoimmune thyroiditis5NP Thyroid 90 mg = 1.5 grainsNoneSymptomsNone known(i) Skin issues
(ii) History of hypothyroidism
(iii) Menopause symptoms (post-hysterectomy)
(iv) Severe joint pain, swelling
(v) Hair loss

LF43N/A(i) Hypothyroidism5NDT, Synthroid3, including iron chelateIntolerance of NDT(i) Coconut
(ii) Sulfa drugs
(i) Weight gain
(ii) Fatigue
(iii) Hormonal imbalance

MF55N/A(i) Autoimmune thyroiditis11NP Thyroid 120 mg7SymptomsNone known(i) Metabolic syndrome
(ii) Menopause

N/A, not available. A full list of comorbidities and medications/supplements is available in Supplemental Table 1.