Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Emergency Medicine
Volume 2017 (2017), Article ID 8796425, 6 pages
https://doi.org/10.1155/2017/8796425
Case Report

Epistaxis as a Common Presenting Symptom of Glanzmann’s Thrombasthenia, a Rare Qualitative Platelet Disorder: Illustrative Case Examples

1The Hemophilia Center at Oregon Health & Science University, Portland, OR, USA
2Carman and Ann Adams Department of Pediatrics, Wayne State University and Children’s Hospital of Michigan, Detroit, MI, USA
3Children’s Hospital of Michigan, Detroit, MI, USA
4Clinical Development, Medical and Regulatory Affairs, Novo Nordisk Inc., Plainsboro, NJ, USA

Correspondence should be addressed to Michael Recht; ude.usho@mthcer

Received 3 October 2016; Accepted 29 January 2017; Published 19 February 2017

Academic Editor: Aristomenis K. Exadaktylos

Copyright © 2017 Michael Recht et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. W. McGarry, “Recurrent epistaxis in children,” BMJ Clinical Evidence, vol. 2013, article 0311, 2013. View at Google Scholar
  2. S. C. L. Leong, R. J. Roe, and A. Karkanevatos, “No frills management of epistaxis,” Emergency Medicine Journal, vol. 22, no. 7, pp. 470–472, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. D. J. Pallin, Y.-M. Chng, M. P. McKay, J. A. Emond, A. J. Pelletier, and C. A. Camargo Jr., “Epidemiology of epistaxis in US emergency departments, 1992 to 2001,” Annals of Emergency Medicine, vol. 46, no. 1, pp. 77–81, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Sandoval, S. Dong, P. Visintainer, M. F. Ozkaynak, and S. Jayabose, “Clinical and laboratory features of 178 children with recurrent epistaxis,” Journal of Pediatric Hematology/Oncology, vol. 24, no. 1, pp. 47–49, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. A. T. Nurden, X. Pillois, and P. Nurden, “Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment,” Expert Review of Hematology, vol. 5, no. 5, pp. 487–503, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. S. J. Israels, M. El-Ekiaby, T. Quiroga, and D. Mezzano, “Inherited disorders of platelet function and challenges to diagnosis of mucocutaneous bleeding,” Haemophilia, vol. 16, no. 5, pp. 152–159, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Alamelu and R. Liesner, “Modern management of severe platelet function disorders,” British Journal of Haematology, vol. 149, no. 6, pp. 813–823, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. J. N. George, J. P. Caen, and A. T. Nurden, “Glanzmann's thrombasthenia: the spectrum of clinical disease,” Blood, vol. 75, no. 7, pp. 1383–1395, 1990. View at Google Scholar · View at Scopus
  9. G. Toogeh, R. Sharifian, M. Lak, R. Safaee, A. Artoni, and F. Peyvandi, “Presentation and pattern of symptoms in 382 patients with Glanzmann thrombasthenia in Iran,” American Journal of Hematology, vol. 77, no. 2, pp. 198–199, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Rajpurkar, S. H. O'Brien, F. W. Haamid, D. L. Cooper, S. Gunawardena, and M. Chitlur, “Heavy menstrual bleeding as a common presenting symptom of rare platelet disorders: illustrative case examples,” Journal of Pediatric and Adolescent Gynecology, vol. 29, no. 6, pp. 537–541, 2016. View at Publisher · View at Google Scholar
  11. A. T. Nurden, “Glanzmann thrombasthenia,” Orphanet Journal of Rare Diseases, vol. 1, article 10, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Jagminas and M. Daniel, “Management of Epistaxis in the Emergency Department,” AHC Media, 2006.
  13. C. J. Kucik and T. Clenney, “Management of epistaxis,” American Family Physician, vol. 71, no. 2, pp. 305–311, 2005. View at Google Scholar · View at Scopus
  14. P. Harrison, “The role of PFA-100® testing in the investigation and management of haemostatic defects in children and adults,” British Journal of Haematology, vol. 130, no. 1, pp. 3–10, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Cattaneo, “Light transmission aggregometry and ATP release for the diagnostic assessment of platelet function,” Seminars in Thrombosis and Hemostasis, vol. 35, no. 2, pp. 158–167, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. B. A. Konkle, “Acquired disorders of platelet function,” Hematology. American Society of Hematology. Education Program, vol. 2011, no. 1, pp. 391–396, 2011. View at Google Scholar
  17. M. Kannan, F. Ahmad, B. K. Yadav et al., “Carrier detection in Glanzmann thrombasthenia: comparison of flow cytometry and Western blot with respect to DNA mutation,” American Journal of Clinical Pathology, vol. 130, no. 1, pp. 93–98, 2008. View at Publisher · View at Google Scholar · View at Scopus