Case Report

Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome

Table 1

FXTAS clinical, neuroimaging, and molecular results of the patient.

Intention tremorbegan at age 55
Right upper extremityPostural tremor (+)
Kinetic tremor (+)
Left upper extremityPostural tremor (+)
Kinetic tremor (+)
Handwriting problemsbegan at age 58
Balance problembegan at age 58
Type of gaitAtaxic and broad based
Dependent on walkerBegan at age 66
Memory problemsBegan at age 63
Fragile X DNA test (CGG repeat number)98–103 (premutation range)
FMR1 mRNA level 2 . 3 3 ± 0 . 0 2 times normal
FXTAS diagnosisDefinite
FXTAS stage4