Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis
(a) Karyotype of bone marrow cell by G-banding showing 47,XY,+11,t(15; 17)(q22; q21). (b, c) Hybridization of LSI PMLRARA dual-color DNA probe (Cytocell, Cambridge, UK). The probe hybridizes to chromosome 15q11 (SpectrumOrange PML), 17q21.1 (SpectrumGreen RARA). Fusion signal of PML/RARA gene was clearly observed in 70% of the nucleus and metaphases. (d) Fish using LSI MLL dual color break-apart probe. Nucleus with three and others with two signals, confirming trisomy 11 in some of them.