First Trimester Diagnosis of Holoprosencephaly Secondary to a Ring Chromosome 7

<table>Cytogenetic and molecular analysis of ring chromosome 7. Partial karyotype showing the normal chromosome 7 and r(7) (p22.3q36.1) (inset). Ideogram illustrating the 9.7 Mb deleted region defined by aCGH (red bar) and UCSC Genome Browser display of OMIM genes within the deletion (GRCh37/hg19). Known disease-causing genes, including <i>SHH</i> and <i>MNX1</i>, are represented by darker bars.</table>

Case Reports in Genetics

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Figure 2

Figure 2: First Trimester Diagnosis of Holoprosencephaly Secondary to a Ring Chromosome 7 