Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Genetics
Volume 2014, Article ID 921240, 4 pages
http://dx.doi.org/10.1155/2014/921240
Case Report

A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13)

1Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
2University of Oklahoma Health Sciences Center, Stephenson Cancer Center, 800 NE 10th Street, Oklahoma City, OK 73102, USA
3Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
4Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA

Received 31 July 2014; Revised 15 October 2014; Accepted 18 October 2014; Published 11 November 2014

Academic Editor: Philip D. Cotter

Copyright © 2014 Mohamad Khawandanah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Gary Gilliland and J. D. Griffin, “The roles of FLT3 in hematopoiesis and leukemia,” Blood, vol. 100, no. 5, pp. 1532–1542, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. C. H. Kok, A. L. Brown, M. Perugini, D. G. Iarossi, I. D. Lewis, and R. J. D'Andrea, “The preferential occurrence of FLT3-TKD mutations in inv(16) AML and impact on survival outcome: a combined analysis of 1053 core-binding factor AML patients,” British Journal of Haematology, vol. 160, no. 4, pp. 557–559, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J. C. Cigudosa, N. Z. Parsa, D. C. Louie et al., “Cytogenetic analysis of 363 consecutively ascertained diffuse large B-cell lymphomas,” Genes Chromosomes Cancer, vol. 25, pp. 123–133, 1999. View at Google Scholar
  4. N. L. Harris, E. S. Jaffe, H. Stein et al., “A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group,” Blood, vol. 84, no. 5, pp. 1361–1392, 1994. View at Google Scholar · View at Scopus
  5. N. A. Heerema, H. N. Sather, M. G. Sensel et al., “Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group,” Journal of Clinical Oncology, vol. 16, no. 4, pp. 1270–1278, 1998. View at Google Scholar · View at Scopus
  6. M. Hanada, D. Delia, A. Aiello, E. Stadtmauer, and J. C. Reed, “bcl-2 Gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia,” Blood, vol. 82, no. 6, pp. 1820–1828, 1993. View at Google Scholar · View at Scopus
  7. H. Avet-Loiseau, T. Facon, B. Grosbois et al., “Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation,” Blood, vol. 99, no. 6, pp. 2185–2191, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Gao, H. Wu, D. He et al., “Downregulation of BCL11A by siRNA induces apoptosis in B lymphoma cell lines,” Biomedical Reports, vol. 1, pp. 47–52, 2013. View at Google Scholar
  9. O. A. Bernard, M. Busson-LeConiat, P. Ballerini et al., “A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia,” Leukemia, vol. 15, no. 10, pp. 1495–1504, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Bezrookove, S. L. van Zelderen-Bhola, A. Brink et al., “A novel t(6;14)(q25~q27;q32) in acute myelocytic leukemia involves the BCL11B gene,” Cancer Genetics and Cytogenetics, vol. 149, no. 1, pp. 72–76, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. J. L. Oliveira, R. Kumar, S. P. Khan et al., “Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion,” Pediatric Blood & Cancer, vol. 56, no. 3, pp. 467–469, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Ahmad, R. Dalvi, S. Mandava, and B. R. Das, “Acute Myelogeneous Leukemia (M0/M1) with novel chromosomal abnormality of t(14;17) (q32; q11.2),” The American Journal of Hematology, vol. 82, no. 7, pp. 676–678, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Tecimer, B. A. Loy, and A. W. Martin, “Acute myeloblastic leukemia (M0) with an unusual chromosomal abnormality: Translocation (1;14)(p13;q32),” Cancer Genetics and Cytogenetics, vol. 111, no. 2, pp. 175–177, 1999. View at Publisher · View at Google Scholar · View at Scopus