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Case Reports in Genetics
Volume 2015, Article ID 827656, 4 pages
http://dx.doi.org/10.1155/2015/827656
Case Report

Early Morphokinetic Monitoring of Embryos after Intracytoplasmic Sperm Injection with Fresh Ejaculate Sperm in Nonmosaic Klinefelter Syndrome: A Different Presentation

1Department of Obstetrics and Gynecology, Novafertil IVF Center, Meram Yeni Yol No. 75, Meram, 42090 Konya, Turkey
2Department of Urology, Novafertil IVF Center and Konya Hospital, Meram Yeni Yol No. 75, Meram, 42090 Konya, Turkey
3Medicana Konya IVF Center, Medicana Konya Feritpaşa Mah., Gurz Sok. No. 1, Selçuklu, 42060 Konya, Turkey
4Department of Medical Genetic, Meram Tip Faculty, Necmettin Erbakan Universıty, Yunus Emre Mah., Meram, 42060 Konya, Turkey

Received 27 October 2015; Accepted 20 December 2015

Academic Editor: Balraj Mittal

Copyright © 2015 Ali Sami Gurbuz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The patient was diagnosed with nonmosaic 47, XXY Klinefelter Syndrome with the AZF deletion absent and SRY+. The nonmosaic 47, XXY karyotype was confirmed on a skin biopsy chromosomal analysis. Using only ejaculate motile sperms, 11 oocytes underwent ICSI and were placed rapidly in a time lapse (Embryoscope ©) with a specific culture dish. Biopsies were performed on six embryos on the 3rd day, and numerical chromosomal abnormalities were observed using the FISH test before transfer. PGS results were normal in only two embryos with normal morphokinetics in the Embryoscope. For clinical confirmation of pregnancy, ultrasonographic examination was performed during the 7th week of pregnancy, and two gestational sacs and fetal heart beat were observed.