A Specific Diplotype H1j/H2 of the MAPT Gene Could Be Responsible for Parkinson’s Disease with Dementia

Table 3

Clinical features of the 3 Moroccan PD patients with the MAPT H2/H1j genotype.

Patients	3592	3793	3894
Sex	M	M	F
Consanguinity	−	−	−
Age at onset	41	47	47
Disease duration	7 years	1 year	3 years
Initial symptom	Akinesia	Akinesia	Akinesia
Clinical form	Akinetic-rigid	Akinetic-rigid	Mixed
Resting tremor	−	−	+
Akinesia	+	+	+
Rigidity	+	+	+
Dystonia	−	−	−
Gait impairment	−	+	+
Postural instability	−	−	−
UPDRS III (on)	11	10	18
H–Y score	1	1.5	2
Motor fluctuation	+	−	+
Levodopa induced dyskinesia	+	−	−
Levodopa equivalent dose	1032	400	600
Urinary dysfunction	−	−	−
Orthostatic HypoTA	−	−	+
Pain	−	+	+
Constipation	+	−	+++
Sleep disorder	+	−	+
Psychiatric features	−	−	−
Cognitive decline	+	−	+