Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma

Figure 3

Schematic of KIT variants from the index patient and TCGA sarcoma database. The KIT V603D missense variant of the index patient is seen in the protein tyrosine kinase domain of the protein. The remaining four variants reported in three patients from the TCGA sarcoma database are plotted, including the frameshift variants (W557Gfs18 and Q556Rfs8) in a case of leiomyosarcoma, the R804Q missense variant in a separate case of leiomyosarcoma, and the C906R missense variant in a case of malignant peripheral nerve sheath tumor.