A Chinese Patient with Spastic Paraplegia Type 4 with a De Novo Mutation in the SPAST Gene

Figure 3

Pedigree of the patient’s family. The gray arrow indicates the proband II:5 of the SPAST and NEFH mutations. Squares indicate males, and circles indicate females. Individuals carrying the NEFH mutation are represented by black-filled symbols, whereas empty symbols indicate healthy individuals without the NEFH or SPAST mutation. The presence of the SPAST mutation alone was not observed in any family member.