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Case Reports in Gastrointestinal Medicine
Volume 2011, Article ID 938580, 3 pages
Case Report

Nodular Regenerative Hyperplasia and Portal Hypertension in a Patient with Coeliac Disease

1Department of Gastroenterology and Hepatology, HELIOS Klinikum Siegburg, Ringstraße 49, 53721 Siegburg, Germany
2Department of Pathology, University Hospital Bonn, Sigmund-Freud Straße 25, 53105 Bonn, Germany

Received 18 May 2011; Accepted 4 July 2011

Academic Editors: F. Francois, I. C. Lawrance, and N. Suzuki

Copyright © 2011 Erwin Biecker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nodular regenerative hyperplasia (NRH) of the liver is often associated with rheumatologic or lymphoproliferative disorders and a cause of portal hypertension in some patients. We report the case of a 71-year-old patient with celiac disease and unexplained portal hypertension. Biopsy of the liver revealed NRH as the underlying cause. The patient did not suffer from an autoimmune, rheumatologic or lymphoproliferative disease. A thrombophilic disorder that might cause NRH was ruled out. Celiac disease is often associated with mild elevation of liver enzymes and steatosis of the liver, but the association with NRH was described in only a few patients. We discuss the possible relationship of celiac disease and NRH.