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Case Reports in Gastrointestinal Medicine
Volume 2012 (2012), Article ID 185730, 3 pages
http://dx.doi.org/10.1155/2012/185730
Case Report

Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination

1Department of Medicine, Hepatology and Gastroenterology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Denmark
2Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgaardsvej 21 C, 8200 Aarhus N, Denmark
3Institute of Pathology, Vendsyssel Hospital, Bispensgade 37, 9800 Hjorring, Denmark

Received 12 October 2012; Accepted 2 November 2012

Academic Editors: P. Abraham, V. Lorenzo-Zúñiga, N. Matsuhashi, and Ö. Yönem

Copyright © 2012 Tine Gregersen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix. Neurofibromatosis type 1 is an autosomal dominant disorder caused by a mutation in the NF1 gene. Patients with neurofibromatosis type 1 have an increased incidence of typical neuroendocrine tumors, but it is unknown if this is the case with goblet cell carcinoids. We describe a patient with both neurofibromatosis type 1 and goblet cell carcinoid, that according to literature would occur in 0.00017 per million per year. This may suggest a previously unknown association between neurofibromatosis type 1 and goblet cell carcinoids.