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Case Reports in Gastrointestinal Medicine
Volume 2013, Article ID 902892, 3 pages
Case Report

Adderall Induced Acute Liver Injury: A Rare Case and Review of the Literature

1Beth Israel Deaconess Medical Center, Division of Gastroenterology, 330 Brookline Avenue, Dana 603, Boston, MA 02215, USA
2Washington Hospital Center, Division of Gastroenterology, 110 Irving Street, Washington, DC 20010, USA
3St. Joseph’s Hospital and Medical Center, Division of Gastroenterology, 500 W Thomas Road, Suite 900A, Phoenix, AZ 85013, USA

Received 28 May 2013; Accepted 18 June 2013

Academic Editors: I. M. Leitman, R. J. L. F. Loffeld, V. Lorenzo-Zúñiga, Y. Nakayama, and Ö. Yönem

Copyright © 2013 Rohini R. Vanga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Adderall (dextroamphetamine/amphetamine) is a widely prescribed medicine for the treatment of attention-deficit/hyperactivity disorder (ADHD) and is considered safe with due precautions. Use of prescribed Adderall without intention to overdose as a cause of acute liver injury is extremely rare, and to our knowledge no cases have been reported in the English literature. Amphetamine is an ingredient of recreational drugs such as Ecstacy and is known to cause hepatotoxicity. We describe here the case of a 55-year-old woman who developed acute liver failure during the treatment of ADHD with Adderall. She presented to the emergency room with worsening abdominal pain, malaise, and jaundice requiring hospitalization. She had a past history of partial hepatic resection secondary to metastasis from colon cancer which was under remission at the time of presentation. She recovered after intensive monitoring and conservative management. Adderall should be used carefully in individuals with underlying liver conditions.