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Case Reports in Gastrointestinal Medicine
Volume 2017 (2017), Article ID 2416901, 3 pages
Case Report

Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease

University of Illinois at Chicago/Christ Hospital Advocate Medical Center, Oak Lawn, IL, USA

Correspondence should be addressed to Natasha Shah

Received 1 December 2016; Accepted 10 April 2017; Published 26 April 2017

Academic Editor: Hideto Kawaratani

Copyright © 2017 Natasha Shah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Elevated carbohydrate antigen 19-9 (CA19-9) beyond 1000 U/L occurs in nonneoplastic conditions which is causing questioning of the use of CA19-9 as a marker for screening. We report a case where a 51-year-old male with Mirrizi Syndrome (MS) presented with markedly increased CA19-9 level (4,618 U/mL). MS is a rare complication characterized by compression of the common bile or hepatic duct caused by an impacted gallstone in the cystic duct or neck of the gallbladder. Biliary epithelial cells secrete CA19-9: it is hypothesized that increased proliferation of such cells caused by inflammation leads to increased secretion. CA19-9 should not be used as a diagnostic tool, but rather for surveillance.