A Case Report and Literature Review of Clostridium difficile Negative Antibiotic Associated Hemorrhagic Colitis Caused by Klebsiella oxytoca

Table 1

Literature review of case reports of colitis secondary to Klebsiella oxytoca.

Author	Year and Location	Patient Age and Gender	Presenting symptoms	Antibiotic prior to presentation	NSAID use prior to presen- tation	Duration of Abx prior to sx	Endo- scopic location of disease	Time to reso- lution of sx	Treatment
Koga et al. [6]	1999 Japan	37 y/o Female	Bloody diarrhea and abdominal pain	Tosu- floxacin tosylate 450 mg	none	5 days∗	Entire colon excluding rectum	2 weeks	Hydration and Loperamide
Koga et al. [6]	1999 Japan	46 y/o Male	Bloody diarrhea and abdominal pain	Enoxacin	none	7 days∗	Right sided	3 weeks	Supportive
Koga et al. [6]	1999 Japan	37 y/o Male	Bloody diarrhea	Levo- floxacin 300 mg	none	7 days∗	Transverse to sigmoid	3 weeks	Supportive
Chen, Cachay, and Hunt [7]	2004 San Diego, CA	79 y/o Male	Diarrhea, abdominal pain, hemato- chezia	none	Aspirin	none	Sigmoid colon	2 weeks	Cipro- floxacin
Philbrick, Ernst [8]	2007 Iowa	63 y/o Male	Watery diarrhea and BRBPR	Amoxicillin 500 mg q8h	Ibuprofen 800mg q8h	5 days	Ascending to descending colon	1 week	Metro- nidazole and Levo- floxacin
Miyauchi, Kinoshita, Tokuda [9]	2013 Japan	67 y/o Female	Mucobloody diarrhea and abdominal pain	Clarithro- mycin 200 mg q12h	none	5 days	Right sided	Not specified	Supportive
Sweetser, Schroede, Pardi [10]	2009 Rochester, MN	67 y/o Female	Watery diarrhea	Peri- operative abx	none	3 days	Sigmoid colon	4 days	Supportive
Kazuyuki et al. [11]	2017 Japan	65 y/o Female	Abdominal pain and hemato- chezia	Amoxicillin 1500 mg and Metro- nidazole 500 mg	none	1 day	Transverse colon	6 days	Bowel rest and prednisolone
Akanbi et al.[12]	2017 Chicago, IL	85 y/o Female	Abdominal pain and muco- bloody diarrhea	Amoxicillin - clavulanic acid	none	5 days	Declined colon- oscopy	5 days	Supportive care

^∗Symptoms did not start until ~3-4 weeks after antibiotic cessation.
Q8h, every 8 hours; q12h, every 12 hours; BRBPR, bright red blood per rectum; abx, antibiotics; ASA, aspirin; sx, symptoms; y/o, years old.