Blue Rubber Bleb Nevus Syndrome with Long-Term Follow-Up: A Case Report and Review of the Literature

Table 1

Review of cases of blue rubber bleb nevus syndrome with venous malformations on the gastrointestinal tract.

No.	Year	Sex	Age at onset	Age at treatment	Sites of lesions	Treatment	Outcome	follow up period from the 1st / last treatment (year)
1	2001 [3]	F	0	0	—	right colectomy	—	37 / —
				0–6	—	partial gastrectomy, small bowel resection, total colectomy	blood transfusions required
				34–37	small intestine, rectum	endoscopic sclerotherapy	oral iron, vitamin and caloric supplementation
2	1996 [4]	F	6	7	intestine	surgical resection	stable for 5 years	25 / 5
				13	small intestine, colon	surgical resection	stable for 5 years
				26	duodenum, ileum, colon	surgical resection	stable for 5 years
3	1997 [5]	M	5	9	stomach	endoscopic electrocautery	oral iron supplements and blood transfusions required	21 / 1
				23	stomach, duodenum, small intestine, colon	intraoperative endoscopic polypectomy, surgical resection	stable for 1 year
4	1990 [6]	F	9	9	whole GI tract	endoscopic sclerotherapy (for the upper and lower GI)	GI bleeding continued	13 / short period
				15	whole GI tract	surgical resection	stable for 4 years
				19	upper and lower GI tract	intraoperative endoscopic electrocautery, surgical resection	stable for the short period
5	2013 [7]	F	1	12	stomach	surgical resection	—	13 / 3.5
				22	colon	endoscopic ligation and sclerotherapy	stable for 3.5 year
6	2005 [8]	F	19	19	colon	endoscopic clipping	stable for 5 years	7 / short period
				25	small intestine, colon	endoscopic clipping and polypectomy, surgical resection	stable for the short period
7	2009 [9]	M	0	2	stomach, colon	endoscopic electrocautery (for the stomach)	blood transfusions required for 4 years	7
8	2003 [10]	F	0	0	colon	endoscopic APC	stable for 5 years	5
9	2007 [11]	F	8	12	stomach, small intestine, colon	Surgical wedge resection, intraoperative endoscopic sclero-coagulation	stable for 5 years	5
10	2010 [12]	M	4	4	stomach, colon	endoscopic sclerotherapy	—	5 / 3
				6	small intestine	surgical resections through enterotomies	stable for 3 years
11	Our case	F	4	5	stomach, small intestine, colon	surgical resection	stable for 10 years with oral iron supplementation	19 / 5
				19	stomach, duodenum, small intestine, colon	surgical resection, APC	stable for 5 year

“—” means no data described; GI: gastrointestinal; APC: argon plasma coagulation.