McKittrick-Wheelock Syndrome Presenting with Acute Kidney Injury and Metabolic Alkalosis: Case Report and Narrative Review
Table 2
Demographic and clinical characteristics of patients.
Total number of patients
49
Age
Mean (years)
63.5
Min (years)
26
Max (years)
84
ND
3
Sex, N ()
Female
24 (49.0)
ND
3 (6.1)
Hemodynamic state, N ()
Hypotension and/or tachycardia
16 (32.7)
Stable
3 (6.1)
ND
30 (61.2)
Diarrhea, N ()
YES
42 (85.7)
NO
1 (2.0)
ND
6 (12.2)
Remarkable features, N ()
Prolapse
3 (6.1)
Intussusception
1 (2.0)
Reversible diabetes
2 (4.1)
Infectious endocarditis (E. Faecalis)
1 (2.0)
Familial adenomatous polyposis syndrome
1 (2.0)
Cronkhite-Canada syndrome
1 (2.0)
Lab tests
Median creatinine, μmol/L (max; IQR)
359 (1440; 447.75); 21 ND
Median sodium, meq/L (min; IQR)
118 (93; 13.5); 20 ND
Median potassium, meq/L (min; IQR)
2.6 (1.3; 0.75); 16 ND
Median chloride, meq/L (min; IQR)
67 (<45; 22.5); 36 ND
Median bicarbonates, meq/L (min; max; IQR)
16 (7.2; 31; 15.6); 38 ND
Acidosis present (pH <7,35), N (%)
6 (12.2); 42 ND
Alkalosis present (pH >7,45), N (%)
1 (2.0); 42 ND
Pathology, N ()
Benign
13 (26.5)
HGD/Cis
11 (22.4)
Adenocarcinoma
9 (18.4)
Other
1 (2.0)
ND
15 (30.6)
Management, N ()
Surgery†
31 (63.3)
Minimally invasive surgery†
9 (18.4)
Medical†
5 (10.2)
No treatment
4 (8.2)
ND
2 (4.1)
Pathology showed a neuroendocrine tumor [1]. †One patient was treated medically before surgery [2]; another patient underwent transanal minimally invasive surgery (TAMIS) and then surgery one year later for recurrence [3]. ND = not determined; min = minimum value; max = maximum value; IQR = interquartile range; HGD = high grade dysplasia; Cis = carcinoma in situ.
