Benign Recurrent Intrahepatic Cholestasis (BRIC): An African Case Report

Table 3

Diagnostic criteria.

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Diagnostic criteria for BRIC (LUKETIC and SHIFFMAN, 2004)

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At least two attacks of jaundice separated by a symptom-free interval lasting several months to years

Laboratory values consistent with intrahepatic cholestasis

GGT either normal or only minimally elevated

Severe pruritus secondary to cholestasis

Liver histology demonstrating centrilobular cholestasis

Normal intra- and extrahepatic bile ducts by cholangiography

Absence of factors known to be associated with cholestasis (i.e., drugs and pregnancy)

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