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| Author and year | Presentation and diagnostic work-up | Medication | Outcome |
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| 1. Kirkpatrick A. R., 1978 [8] | A 27-year-old male with abdominal pain, gross bloody stool, and pallor, diagnosed using the Tc-99 m scan. The patient initially refused surgery due to financial reasons | Cimetidine 300 mg 4x/day per os. | Hemoglobin stabilized, and symptoms resolved for three months. Bleeding recurred upon stopping medication, and surgery was performed |
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| 2. Colins, J. C. Jr., 1980 [9] | A 26-year-old female with rectal bleeding and abdominal pain. Initial diagnosis was made with barium studies; it was confirmed with the Tc-99 m scan | Cimetidine initially i.v. and then per os. | There was no further bleeding. Elective surgery was performed 10 days later. Microscopic examination reiterated the diagnosis |
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| 3. Selker H. P., 1983 [10] | A 23-year-old male with postprandial infraumbilical pain, stool occult blood, and microcytic hypochromic anemia. Barium studies demonstrated a large ileal diverticulum; the Meckel scan was normal | Cimetidine 400 mg 4x/day per os. | Medication was stopped, and bleeding recurred. Cimetidine was restarted with good response, and surgery was performed five days later. Microscopic examination confirmed the diagnosis and demonstrated gastric-like mucosa |
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| 4. Xinias I. et al., 2012 [11] | An 8-year-old boy with bright red stools, eventually diagnosed with wireless capsule endoscopy | Ranitidine 6 mg/kg of body weight 2x/day per os. | Maintained symptom free for six months, after which surgery was performed. Microscopic examination confirmed the diagnosis |
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| 5. Dashan A., 2006 [12] | A 9-year-old boy with overt gastrointestinal bleeding. Diagnosis was made with isotope scanning | Pantoprazole 40 mg/day i.v. | Symptoms resolved, and surgery was performed 4 days after initial presentation |
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| 6. Ottaviano L. F. et al., 2016 [13] | A 72-year-old female with beta-thalassemia trait presented with weakness and anemia. Double-balloon enteroscopy found midileal diverticulum with adjacent ulcer | PPI | The patient refused surgery, and at 7 months’ follow-up, hemoglobin remained stable with no new episodes of melena or overt GI bleeding |
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| 7. Ottaviano L. F. et al., 2016 [13] | An 80-year-old male with abdominal pain and anemia. CT showed distal small-intestinal wall thickening, and video capsule endoscopy demonstrated an ulcer. Double-balloon enteroscopy showed a nonbleeding jejunal angioectasia (treated with argon plasma coagulation) and ulcerated midileal mucosa surrounding a small diverticulum | PPI | Symptom resolution up to study date |
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| 8. Manning R. J., 1987 [14] | A 25-year-old male with copious gastrointestinal bleeding | Cimetidine 300 mg 4x/day and ranitidine 150 mg 3x/day per os. | Despite two H2 blockers and aggressive i.v. fluid and blood replacement, bleeding persisted, and emergent surgery was performed. Meckel’s diverticulum was found intraoperatively and confirmed microscopically |
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