Case Report

CMV-Related Gastric Ulcer and Gastroduodenitis in an Immunocompetent Patient: A Case Report and Literature Review

Table 1

Summary of published data from previous cases of gastric cytomegalovirus disease in immunocompetent patients.

Ref.Age/genderComorbiditiesSymptomsEndoscopic findingsHistologic findingsTreatmentFollow-up endoscopy

Crespo et al. [11]31/maleNoneEpigastric pain, feverSuperficial erosions of the gastric antrumInclusion bodies and positive IHC stainingIV ganciclovir 5 mg/kg twice daily for 7 daysFull resolution, time of repeated endoscopy is not mentioned

Fyock et al. [12]83/maleDMMelenaGastritis with multiple small antral, duodenal, and colonic ulcersInclusion bodies and positive IHC staining, culture, and PCR21-day course of oral ganciclovir followed by IV administrationPartial healing of the duodenal ulcers after the antiviral therapy; full resolution 4 years later with the persistence of CMV

Ebisutani et al. [13]33/maleNoneEpigastric pain, low-grade fever, coughMultiple gastric papules and a large irregularly shaped shallow ulcerPositive IHC staining in the absence of inclusion bodiesOral PPI (rabeprazole, 20 mg/day)Small gastric ulcer on day 40; a residual ulcer scar on day 68

Matsui et al. [14]29/maleN/AEpigastric pain, feverMultiple shallow gastric ulcers and mucosal erosionsPositive PCR for CMV-DNA in the absence of inclusion bodiesOral PPIFull resolution 2 months later

Himoto et al. [15]31/maleNoneEpigastric pain, feverMultiple shallow gastric ulcers and mucosal edemaInclusion bodies and positive IHC stainingOral PPI (lansoprazole, 30 mg/day)Full resolution 2 months later

Xiong et al. [16]44/maleNoneEpigastric pain, abdominal distentionMultiple erosions in the gastric antrum and thickening of the stomach wallInclusion bodies and positive IHC staining, negative PCR for CMV-DNAIV ganciclovir for 3 monthsFull resolution 3 months later

Yamamoto et al. [17]35/maleNoneInfectious mononucleosis syndromeThickened and eroded mucosa throughout the stomachPositive IHC staining in the absence of inclusion bodiesNoneImprovement, time of repeated endoscopy is not mentioned

CMV-EBV coinfection.