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Case Reports in Hematology
Volume 2011, Article ID 670603, 3 pages
Case Report

CML Developing Three Years after Therapy Completion in a Child with Ph(−) Pre-B-ALL

1Hematology Laboratory, Hematology Oncology Ward, Ali Asghar Children Hospital, Tehran, Iran
2Tehran University of Medical Science, Tehran, Iran

Received 29 June 2011; Accepted 14 July 2011

Academic Editors: S. Aref and M.-C. Kyrtsonis

Copyright © 2011 S. Hosseini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a girl with a history of Ph(−) pre-B-ALL and three years of disease-free survival admitting to our hospital for regular end of treatment checkup with an increased white blood cell count which in follow-up studies and molecular detection of BCR-ABL (p210) fusions gene had been diagnosed as a Ph(+) typical CML. The upcoming question in this case scenario is whether developed CML is a secondary leukemia due to previous ALL chemotherapy or just a relapse case of primary leukemia.