Deep Vein Thrombosis, Raynaud's Phenomenon, and Prinzmetal Angina in a Patient with Glanzmann Thrombasthenia

Table 1

Patients with DVT described in the literature and this study.

Patient	Bleeding	Platelet Aggreg	Residual 𝛼IIb𝛽3	Mutation	Ref	Comments
N° 1—elderly male	Mild	Absent	50%	𝛽3-Ser752Pro	[12]	Severe proximal DVT and pulmonary embolism after long airflight—treated with LMWH
N° 2—adult male	GI bleeding	Absent	Absent/low	Not known	[9]	Recurrent (3X) proximal DVT in same leg. Factor V Leiden. Treated with LMWH
N° 3—adult male	Mild	Absent	Absent	Not known	[10]	Recurrent DVT & possible pulmonary embolism. Factor V Leiden. Treated with heparin and warfarin
N° 4—2-yr-old girl	Repeated epistaxis	Absent	Much reduced	Not known	[11]	Proximal DVT after platelet transfusions (femoral catheter) and rFVIIa. No anticoagulation
N° 5—adult woman	Moderate	Absent	Trace amounts	𝛽3-Cys457Tyr	[1] (patient 11); [22]	Single episode treated with heparin
N° 6—adult woman	Severe when child	Absent	Absent	𝛼IIb-Glu324Lys	[1] (patient 9); and this study	Single episode without treatment; Raynaud’s phenomenon and Prinzmetal angina

Patients were included on the basis of a detailed literature report and of the availability of clinical and biological data. Mutations are given when known. LMWH: low molecular weight heparin. rFVIIa: recombinant factor VIIa. Aggreg: aggregation.