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Case Reports in Hematology
Volume 2012, Article ID 803298, 4 pages
Case Report

Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma

Department of Medical Oncology (Pad. H 5° Piano), University of Messina, Via Consolare Valeria Road 98125 Messina, Italy

Received 14 September 2012; Accepted 17 October 2012

Academic Editors: K. Khair and D. Rund

Copyright © 2012 Vincenzo Pitini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Occult hepatitis B (OBI) is caused by a persistent low-level replication of HBV. Like overt HBV infection, OBI can be associated with the integration of HBV sequences into the host genome and has a substantial clinical relevance for patients who are severely immunosuppressed for long durations. We present the case of a patient with a diffuse large B-cell non-Hodgkin lymphoma and OBI who developed a hepatocellular carcinoma with a fulminant clinical course following the administration of rituximab plus CHOP.