Acute Myeloid Leukemia Evolving from JAK 2-Positive Primary Myelofibrosis and Concomitant CD5-Negative Mantle Cell Lymphoma: A Case Report and Review of the Literature
Primary myelofibrosis, fibrotic stage: (a) peripheral blood smear, Wright-Giemsa stain, blast (arrow), Ob. 100x immersion oil. (b) Hypercellular bone marrow biopsy, Hematoxylin and eosin stain, Ob. 50x (c) bone marrow biopsy with markedly increased reticulin deposition. Ob. 50x, (d) Anti-CD20 antibody highlights a large subset of positive lymphoid cells in a lymphoid aggregate, Ob. 50x. (e) Anti-CD3 antibody highlights a small subset of CD3+ T-cells in a lymphoid aggregate, Ob. 50x. (f) Anti-Cyclin D1 antibody highlights a small subset of positive nuclei in a lymphoid aggregate, Ob. 50x.
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