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Case Reports in Hematology
Volume 2012 (2012), Article ID 954201, 4 pages
http://dx.doi.org/10.1155/2012/954201
Case Report

Systemic Capillary Leak Syndrome as an Initial Presentation of ALK-Negative Anaplastic Large Cell Lymphoma

1Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610-0278, USA
2Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610-0278, USA
3Division of Hematology and Oncology, Department of Medicine, University of Florida College of Medicine, P.O. Box 100278, Gainesville, FL 32610-0278, USA

Received 16 December 2011; Accepted 27 January 2012

Academic Editors: N. Hamerschlak, K. Kawauchi, and E. Nacheva

Copyright © 2012 Laura S. Lourdes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Systemic capillary leak syndrome (SCLS) is a rare disease characterized by third spacing of plasma into the extravascular compartment, leading to anasarca, hemoconcentration, and hypovolemic shock. It has been rarely associated with lymphomas, and reports usually indicate that it occurs after antineoplastic treatment. We present the case of a patient with ALK-negative anaplastic large cell lymphoma who presented with SCLS as the initial manifestation of her lymphoma. The SCLS resolved with treatment of the malignancy with steroids and chemotherapy.