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Case Reports in Hematology
Volume 2013, Article ID 140138, 3 pages
http://dx.doi.org/10.1155/2013/140138
Case Report

Allogeneic Hematopoietic Cell Transplantation for Therapy-Related Myeloid Leukemia following Orthotopic Cardiac Transplantation

1Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
2Section of Hematology/Oncology, Department of Medicine and the Cancer Research Center, University of Chicago, Chicago, IL 60637, USA
3Department of Medicine, Rush University Medical Center, 1725 W. Harrison Street, Ste 836, Chicago, IL 60612, USA

Received 19 February 2013; Accepted 14 March 2013

Academic Editors: D. J. Allsup, E. Bissé, K. Kawauchi, K. Khair, and P. Tsirigotis

Copyright © 2013 Richard J. Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Therapy-related myeloid neoplasm (t-MN) is a subtype of acute myeloid leukemia with adverse cytogenetics and poor overall prognosis despite intensive induction chemotherapy and allogeneic hematopoietic cell transplantation (allo-HCT). It is increasingly recognized as a late complication of chronic immunosuppression in patients who have received solid organ transplantation. In this paper, we describe a case of t-MN following orthotopic cardiac transplantation and its treatment with allo-HCT. We discuss molecular and biological challenges and considerations in double solid organ and bone marrow transplantation and review similar cases at our institution. Our experience suggests general feasibility and safety of allo-HCT in patients who have received solid organ transplantation.