Case Report
More Common Than You Think: Common Variable Immune Deficiency
Table 2
Clinical manifestations of CVID [
8–
13].
| | Symptoms | Chapel et al., 2008 [10] | Oksenhendler et al., 2008 [11] | Quinti et al., 2007 [12] | Cunningham-Rundles and Bodian, 1999 [9] | Hermaszewski and Webster, 1993 [8] | Cunningham-Rundles, 1989 [13] |
Average | | | | | | |
| | Sinusitis, otitis media, bronchitis, and mastoiditis | | 69% | 86% | 98% | 36% | 100% | 75% | | Pneumonia | | 58% | 49% | 79% | 63% | 87% | 69% | | Bronchiectasis | 25% | 37% | | | 18% | | 27% | | Splenomegaly | 30% | 38% | | | 13% | | 27% | | Liver disease | | 17% | | | | | 17% | | Diarrhea | | 23% | 23% | 6% | 12% | | 16% | | Lymphadenopathy | 15% | | | | 5% | | 11% | | Urogenital infection | | | 7% | | 7% | | 7% | | Granulomatous disease | 8% | 14% | 3% | 8% | 1% | | 7% | | Thrombocytopenia | 7% | | 6% | 6% | 3% | 6% | 7% | | Non-Hodgkin’s lymphoma | 3% | | 2% | 8% | | 8% | 5% | | Herpes/varicella | | | | 4% | 7% | 2% | 5% | | Hepatomegaly | 9% | | | | 1% | | 5% | | Hemolytic anemia | 4% | | 3% | 5% | 3% | 5% | 4% | | Pernicious anemia | 9% | | | 1% | 2% | 1% | 4% | | Hepatitis | 2% | | | 7% | 1% | 12% | 4% | | Meningitis/encephalitis | | 8% | 1% | 1% | 7% | 4% | 4% | | Sepsis | | 13% | 1% | 1% | 2% | | 4% | | Malaise | | | | | 3% | | 3% | | Crohn's disease | 2% | | | 4% | | 1% | 3% | | Vitiligo | 5% | | 2% | | 2% | | 3% | | Atopic dermatitis | | | | | 2% | | 2% | | Osteomyelitis | | | | 1% | 3% | 1% | 2% | | Autoimmune neutropenia | 1% | | 3% | 1% | | | 2% | | Stomach cancer | | | 2% | 1% | | 2% | 2% | | Septic arthritis | | | 2% | 1% | 4% | 1% | 2% | | Psoriasis | 2% | | | | 1% | | 1% | | Oral candidiasis | | | 2% | 1% | 1% | | 1% | | Parotitis | | | | 1% | | 1% | 1% |
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