A Unique “Composite” PTLD with Diffuse Large B-Cell and T/Anaplastic Large Cell Lymphoma Components Occurring 17 Years after Transplant

Figure 1

Histopathologic features and immunophenotype of anaplastic appearing area of the lymphoma. (a) The transmural tumor mass in the duodenum with spared small bowel at right (H&E, 20x). (b) Sheets of neoplastic lymphoid infiltrate with anaplastic morphology with horseshoe and ring-shaped multinucleated cells intermixed with other large atypical cells (H&E, 200x). Positive staining for EBER by in situ hybridization (c), TIA-1 (d), CD2 (e), CD30 (f), and variable staining for CD45 wherein most large cells are negative (g). CD20 is absent (h), while PAX5 is present in a nuclear location, as expected (i).