A Unique “Composite” PTLD with Diffuse Large B-Cell and T/Anaplastic Large Cell Lymphoma Components Occurring 17 Years after Transplant

Figure 2

Two distinct components of the lymphoma can be seen in this area of the tumor. (a) H&E section of two distinct components of this lymphoma (20x) with B-cell-like areas marked “B” and T/anaplastic area marked “T.” (b) CD20 stains a distinct area (20x). (c) CD30 positive area is largely CD20 negative (20x). (d) EBER is negative in CD20 positive area (20x). (e) H&E section shows neoplastic lymphoid proliferation in the CD20 positive area (100x). (f) The neoplastic lymphoid cells in CD20 positive area are somewhat less pleomorphic and have fewer multinucleated tumor cells (H&E, 400x). (g) High power view of CD20 positive cells (400x). (h) Positive staining for Kappa light chain (400x). (i) Negative staining for Lambda light chain (400x). (j) Negative EBER by in situ hybridization (400x).